Genomic Unity® Precision Anesthesia Analysis

UO010

Genomic Unity® Precision Anesthesia Analysis is a diagnostic test designed to identify actionable genetic variants associated with possible anesthetic management implications.

Test Description

Genomic Unity® Precision Anesthesia Analysis is a targeted test that uses a whole genome platform to detect all major clinically relevant variant types from a single sample. This targeted test focuses on 22 genes associated with possible anesthetic management implications, enabling providers to implement targeted and preventive pathways.

Genomic Unity® Precision Anesthesia Analysis provides a single, unified clinical report that replaces a battery of tests including: targeted gene panel, single gene analysis and multiplex ligation dependent probe amplification (MLPA), as well as PCR and southern blot tests for selected short tandem repeat expansions and analysis of the MT-ND4 gene m.11232T>C; p.L158P variant, including heteroplasmy levels.

When to Order

Order this test for patients planning to undergo general anesthesia or sedation with a personal or family history of life-threatening anesthetic crises or complications, unexplained sudden cardiac death, or maternal Venezuelan lineage. Key indications include malignant hyperthermia episodes, prolonged neuromuscular paralysis, adverse neurological reactions, unprovoked syncope, or arrhythmias.

Included Genes

BCHE, CACNA1S, CALM1, CALM2, CALM3, CASQ2, CNBP, DSC2, DSG2, DMPK, DSP, KCNH2, KCNQ1, PHOX2B, PKP2, PLN, RYR1, RYR2, SCN5A, STAC3, TMEM43, TRDN

Mitochondrial genes
MT-ND4 gene m.11232T>C; p.L158P variant.

Included Analyses

  • Sequence analysis of genes associated with possible anesthetic management implications including: single nucleotide variants, deletions, insertions, and characterized intronic variants.
  • Copy number variant analysis of genes associated with possible anesthetic management implications including: duplications/deletions, mobile element insertions, and inversions.
  • MT-ND4 gene m.11232T>C; p.L158P variant analysis.
  • Short tandem repeat (STR) analysis of the CNBP, DMPK, and PHOX2B genes. (Learn more).

Optionally includes:

Turnaround Time

A report will be issued within 4 weeks. Turnaround time begins when samples and all required documents and approvals are received.

Sample Types

CPT Codes

81479

The CPT codes provided are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Methods and Limitations

Genomic Unity® Precision Anesthesia Analysis uses a PCR-free whole genome sequencing (WGS) platform paired with our Genomic Intelligence® analytical software.

SNVs:
>99.9% sensitivity
>99.9% specificity
>99.8% positive predictive value

Structural variants:
96% clinical sensitivity

Test limitations:
The following gene is not fully covered: KCNQ1. Therefore there may be sequence changes or structural variants in certain regions of this gene that are not identified with this test.