Genomic Unity® Dementia Analysis

Test Description

Test Code – NR010

Dementia is characterized by a decline in cognitive function – such as thinking, reasoning, personality, and memory – that impact daily life. The two most common causes of hereditary dementia are Alzheimer disease (AD) and frontotemporal dementia (FTD).

Genomic Unity® Dementia Analysis uses a whole genome sequencing platform to diagnose genetic causes of dementia in 34 genes.

When to order

Order this test when clinical symptoms are consistent with dementia. You also have the option to reflex up to Genomic Unity® Exome Analysis or Genomic Unity® Exome Plus Analysis if targeted analysis is non-diagnostic.

Included Analyses

  • Sequence analysis of dementia-associated genes (single nucleotide variants, deletions, insertions, and characterized intronic variants).
  • Copy number variant analysis of dementia-associated genes (duplications/deletions, mobile element insertions, and inversions).
  • Repeat expansion analysis of FTD and/or Amyotrophic lateral sclerosis (ALS)-associated gene C9orf72. (Learn more)
  • Risk for late onset of AD. (APOE status)

Optionally includes:

Included Genes

Note: The GBA gene is not fully covered by this test, therefore not all pathogenic variants may be detected. The APOE genotype is provided for informational purposes only. No interpretation regarding risks associated with this gene are reported. Short tandem repeats are not reported in the PRNP gene.


This test covers many disorders including:

  • Alzheimer Disease
  • Frontotemporal Dementia
  • Hereditary diffuse leukoencephalopathy
  • Lewy body dementia

Test Performance

Sensitivity for SNVs
 >  %
Specificity for SNVs
Positive predictive value for SNVs
Clinical sensitivity for structural variants
Clinical sensitivity for STRs

CPT Codes

81479 (xN), 81405 (xN), 81406 (xN), 81401 (xN), 81404 (xN)

The CPT codes provided are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Accepted Specimens



Specimen Requirements



Specimen Requirements



Specimen Requirements

Turnaround Time

A report will be issued within 4-8 weeks from receipt of all sample requirements.

Contact Us

Please contact customer service to request a kit.

Learn More