OncoAlly™ Comprehensive Hereditary Cancer Analysis

Test Code – OA011

Test Description

OncoAlly™ Comprehensive Hereditary Cancers Analysis uses a whole genome sequencing platform to analyze 87 genes for genetic variants associated with hereditary cancers. For a more focused analysis, consider the OncoAlly™ Common Hereditary Cancers Analysis.

When to Order

Order this test when a patient has a personal or family history suggestive of one or more hereditary cancer predisposition syndromes or when germline variant analysis for hereditary cancer predisposition is necessary to guide medical management.

Included Analyses

Sequence analysis of hereditary cancer-associated genes (single nucleotide variants, deletions, insertions, and characterized intronic variants)
Copy number variant analysis of hereditary cancer-associated genes (duplications/deletions, mobile element insertions, and inversions)

Optionally Includes:

Genomic Unity^® Pharmacogenomics Analysis for broader analysis of 13 variants associated with drug metabolism and pharmacogenetics response

Included Genes

All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Note: The PMS2 gene contains regions that are non-unique, therefore not all variants can be assigned to the correct location, limiting interpretation.

View a list of cancers associated with each gene.

Test Performance

Sensitivity for SNVs

> %

Specificity for SNVs

Positive predictive value for SNVs

Clinical sensitivity for structural variants

CPT Codes

81162, 81432, 81433 , 81435, 81436, 81479

The CPT codes provided are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Accepted Specimens

Blood

5ml

Saliva

2ml

gDNA

5μg

Turnaround Time

A report will be issued within 4 weeks from receipt of required samples.