Gene List and Associated Cancer Type

Gene

Cancer Type

Included in

ABRAXAS1

Breast

ACD

Melanoma

ALK

Neuroblastoma

APC

Colorectal, Gastric, Other

ATM

Breast, Pancreatic, Prostate, Brain, Lymphoid, Other

ATR

Breast, Ovarian, Prostate, Gastric, Other

AXIN2

Colorectal

BAP1

Melanoma, Renal, Other

BARD1

Breast

BLM

Mesothelioma, Lymphoma, Leukemia, Other

BMPR1A

Colorectal, Gastric, Other

BRCA1

Breast, Ovarian, Prostate, Pancreatic, Hematologic, Other

BRCA2

Breast, Ovarian, Prostate, Pancreatic, Other

BRIP1

Ovarian

BUB1B

Renal, Other

CDC73

Parathyroid

CDH1

Gastric, Breast, Colorectal

CDK4

Melanoma, Pancreatic

CDKN1B

Endocrine

CDKN2A

Melanoma, Pancreatic

CEBPA

AML

CHEK2

Breast, Colorectal

CLDN2

Pancreatic

CPA1

Pancreatic

CSF3R

AML, MDS

CTNNA1

Gastric

CTRC

Pancreatic

CTR9

Renal

DDX41

MDS, AML

DICER1

Ovarian, Thyroid, Renal, Other

DIS3L2

Renal

EGFR

Lung

EGLN1

Endocrine

ELP1

Meduloblastoma

EPCAM

Colorectal, Pancreatic, Ovarian, Endometrial

ERBB2

Lung, Pancreatic, Breast

ETV6

ALL, AML, MDS

FH

Renal

FLCN

Renal, Melanoma

FOCAD

Colorectal (Juvenile polyposis syndrome)

GALNT12

Colorectal

GATA2

MDS, AML

GPC3

Renal, Neuroblastoma, Liver

GREM1

Colorectal

GSKIP

AML, CMML

HOXB13

Prostate

HRAS

Rhabdomyosarcoma, Bladder, Neuroblastoma

IKZF1

ALL

KIF1B

Endocrine, Brain

KIT

GIST

LZTR1

Schwannoma, Brain, JMML

MAX

Endocrine

MBD4

AML, Uveal Melanoma, Colorectal

MC1R

Melanoma

MEN1

Thyroid (MTC)

MET

Renal, Lymphoma

MITF

Melanoma, Renal

MLH1

Colorectal, Endometrial

MLH3

Colorectal

MSH2

Colorectal, Endometrial

MSH3

Colorectal

MSH6

Colorectal, Endometrial

MUTYH

Colorectal

NBN

ALL

NF1

MPNST

NF2

Meningioma

NTHL1

Colorectal

PALB2

Breast

PAX5

B-ALL

PDGFRA

GIST

PHOX2B

Neuroblastoma

PMS2

Colorectal

POLD1

Colorectal

POLE

Colorectal

POT1

Melanoma, Brain, CLL, Other

PRKAR1A

Adrenocortical

PRESS1

Pancreatic

PTCH1

Medulloblastoma, BCC, T-ALL

PTEN

Breast, Colorectal, Endometrial, Other

PTPN11

JMML, MPD

RAD51C

Ovarian, Breast

RAD51D

Ovarian, Breast, Prostate

RB1

Retinoblastoma

RECQL4

Osteosarcoma, Skin

RET

Thyroid

RHBDF2

Esophageal

RNASEL

Prostate

RNF43

Colorectal

RPLS

Sarcoma, AML

RPS20

Colorectal

RUNX1

MDS, AML, T-ALL

SAMD9

MDS, AML

SAMD9L

MDS, AML

SDHA

Endocrine, Renal

SDHAF2

Endocrine, Renal

SDHB

Endocrine, Renal

SDHC

Endocrine, Renal, Sarcoma

SDHD

Endocrine, Renal

SLC25A11

Endocrine

SMAD4

Colorectal

SMARCA4

Rhabdoid tumor

SMARCB1

Rhabdoid tumor

SMARCE1

Meningioma

SOS1

Sarcoma, JMML

SPINK1

Pancreatic

SRP72

MDS

STK11

Breast, Ovarian, Pancreatic, Colorectal, Other

SUFU

Medulloblastoma, BCC, T-ALL

TERC

AML

TERF2IP

Melanoma

TERT

MPN, MDS

TMEM127

Renal, Endocrine

TP53

Breast, Pancreatic, Prostate, Colorectal, Other

TRIM2B

Renal

TRIP13

Renal

TSC1

Renal

TSC2

Renal

VHL

Renal, Endocrine

WRN

Osteosarcoma

WT1

Renal, Brain