Introducing Long-Read Whole Genome Sequencing

Tomorrow’s technology, here today.

Genomic Unity® 2.0 – the first and only genetic test that includes both short and long-read sequencing.

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What is long-read whole genome sequencing?

Long-read sequencing extends the capabilities of traditional short-read sequencing. By generating longer, more continuous DNA sequences, it allows for a more detailed and precise analysis of complex regions of the genome. It uncovers variants that are missed by other methods.

Why long-read sequencing matters

Incorporating long-read sequencing into whole genome analysis adds a crucial layer of insight, enabling:

• Better characterization of complex structural variants
• Identification and sizing of repeat expansions of all sizes
• Assessment of disease-associated methylation patterns
• Variant phasing

Genomic Unity® 2.0 – The ultimate genetic test

Genomic Unity® 2.0 is an advanced genomic test that sequences the genome twice – once using short-read sequencing and once using long-read sequencing. This dual approach allows us to uniquely identify the following variant types in a single test:

• Small sequence changes, including intronic and regulatory regions
• Structural variants, including CNVs, inversions, unbalanced translocations, UPD/ROH and aneuploidies
• Mitochondrial variants and large deletions down to 5% heteroplasmy
• Repeat expansions in 44 genes
• Methylation patterns associated with Angelman, Prader-Willi and Fragile X syndromes

Why choose Genomic Unity® 2.0?

Unlike traditional genetic tests that provide partial findings at best, Genomic Unity® 2.0 consolidates information about all variant types into a single, unified clinical report. It replaces the need for:

• Chromosomal microarray (CMA)
• Single gene or targeted gene-panel testing
• Multiplex ligation-dependent probe amplification (MLPA)
• PCR and Southern blog tests for tandem repeat expansions
• Whole exome sequencing (WES)
• Whole genome sequencing (WGS)
• Bisulfite (DNA methylation) sequencing

Order Genomic Unity® 2.0 as a first-line test to significantly shorten the diagnostic process, or reflex up from another test.

When it comes to genetic testing, every detail matters.

Choose wisely. Choose Variantyx.

FAQs

    • Genomic Unity® 2.0 is ideal for patients with:

      • Clinical symptoms linked to multiple genes or genetic mechanisms
      • Atypical presentations

      Genomic Unity® 2.0 can be ordered:

      • As a first-line test
      • When a targeted genetic test is not available
      • When previous test results were non-diagnostic

    • Genomic Unity® 2.0 detects repeat expansions in the following genes: AFF2, AR, ARX, ATN1, ATXN1, ATXN2, ATXN3, ATXN7, ATXN8OS, ATXN10, BEAN1, C9ORF72, CACNA1A, CNBP, CSTB, DIP2B, DMPK, FGF14, FMR1, FOXL2, FXN, GIPC1, GLS, HOXA13, HTT, JPH3, LRP12, NOP56, NOTCH2NLC, PABPN1, PHOX2B, PPP2R2B, PRDM12, PRNP, RFC1, RILPL1, RUNX2, SAMD12, SOX3, TBP, TCF4, VWA1, ZFHX3, and ZIC2.

    • Yes! Genomic Unity® 2.0 is covered by many insurances.

    • You can submit a test requisition form through our Provider Portal or via fax to our Clinical Coordination team.

      If this is your first order with Variantyx, please contact our Clinical Sales Specialists to get your account set up today.

Want to learn more?

Connect with a Clinical Specialist to discuss bringing Genomic Unity® 2.0 testing into your practice today.

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