Genomic Unity® Lightning Genome Analysis

RT100

Genomic Unity® Lightning Genome Analysis is a rapid diagnostic test for acutely ill individuals in the NICU, PICU or ICU designed to identify genetic variants that correlate with the patient’s phenotype.

Test Description

Genomic Unity® Lightning Genome Analysis is a comprehensive test that uses a whole genome platform to detect all major clinically relevant variant types from a single sample. It analyzes patient DNA jointly with parental DNA when family samples are included.

Genomic Unity® Lightning Genome Analysis provides a single, unified clinical report that replaces a battery of tests including: whole exome sequencing (WES), chromosomal microarray (CMA), multiplex ligation dependent probe amplification (MLPA), and single gene or targeted gene panel testing.

Learn More About Rapid Testing With Variantyx

When to Order

Order this test for acutely ill individuals in need of time-sensitive medical or surgical management, such as newborns in neonatal intensive care units (NICUs), children in pediatric intensive care units (PICUs), or adults in intensive care units (ICUs) with a suspected genetic disorder. This test is most appropriate when clinical symptoms may be caused by a variety of genes or genetic mechanisms, are suggestive of multiple conditions, or are atypical for a certain condition.

Included Analyses

  • Genome-wide sequence analysis including: single nucleotide variants, deletions, insertions, intronic, regulatory, and intergenic variants.
  • Genome-wide structural variant analysis including: copy number variants (CNVs), duplications/deletions, regions of homozygosity (ROH), uniparental disomy (UPD)*, mobile element insertions, inversions, and aneuploidy.
  • Mitochondrial genome analysis including: single nucleotide variants, deletions and insertions with heteroplasmy (≥5%), and large deletions.

Optionally includes:

* Available for trio only.

Turnaround Time

A report will be issued in 5 days or less from receipt of required samples.

24/7 customer support can be reached via Lightning@variantyx.com and (tel) 1-508-834-3049, (fax) 1-508-302-0528.

Sample Types

Methods and Limitations

Genomic Unity® Lightning Genome Analysis uses a PCR-free whole genome sequencing (WGS) platform paired with our Genomic Intelligence® analytical software.

SNVs:
>99.9% sensitivity
>99.9% specificity
>99.8% positive predictive value

Structural variants:
96% clinical sensitivity

Mitochondrial variants:
Heteroplasmy is not reported for large deletions and duplications are not detected. The false negative rate for mitochondrial large deletions has not been determined.