Genomic Unity® Neurology Analysis

Neurological disorders are particularly difficult to diagnose due to their heterogeneous nature. While the age of onset and exact symptoms vary from patient to patient, most neurological disorders persist throughout the patient's life and are progressively debilitating. An early diagnosis can be instrumental in determining likely prognosis and guiding clinical management to delay onset of additional symptoms.

Genomic Unity® Neurology Analysis is an effective test for the genetic cause of many neurological disorders including:

checkmarkBrain malformations

checkmarkEpilepsy disorders

checkmarkMotor neuron disorders

checkmarkMovement disorders

checkmarkNeurodevelopmental disorders

checkmarkNeuromuscular disorders

checkmarkNeuropathies

Order this test when the patient presents with neurological symptoms, and you'd like the option to reflex up to Genomic Unity® Exome Plus Analysis.

checkmark Sequencing analysis of neurology associated genes

checkmark Del/dup analysis of neurology associated genes

checkmark Mitochondrial genome analysis with heteroplasmy (≥5%)

checkmark Adult-onset movement disorder (with or without cognitive involvement) STR analysis: AR, ATN1, ATXN1, ATXN2, ATXN3, ATXN7, ATXN8OS, ATXN10, C9ORF72, CACNA1A, CNBP, CSTB, DMPK, FMR1, FXN, PP2R2B

checkmarkEarly-onset intellectual disability disorder STR analysis: AFF2, AFF3, DIP2B, FMR1

Optionally includes:

checkmark Huntington-related STR analysis (requires special consent): HTT, JPH3

checkmark Reflex to Genomic Unity™ Exome Plus Analysis

A2M, AAAS, AANAT1, AARS1, AARS2, AASS, ABAT, ABCA1, ABCA7, ABCB7, ABCC6, ABCC8, ABCD1, ABCD4, ABHD12, ABHD5, ACACA, ACAD9, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACE, ACER3, ACKR1, ACO2, ACOX1, ACSF3, ACSL4, ACTA2, ACTAT1, ACTB, ACTG1, ACVRL1, ACY1, ADAM10, ADAR, ADCK3, ADCY5, ADGRG1, ADGRV1, ADK, ADNP, ADSL, AFF2, AFG3L2, AGA, AGK, AGL, AGRN, AGXT, AHCY, AHDC1, AHI1, AIFM1, AIMP1, AKT1, AKT3, ALAD, ALAS2, ALDH181, ALDH18A1, ALDH3A2, ALDH4A1, ALDH5A1, ALDH5A2, ALDH6A1, ALDH7A1, ALDH7A2, ALDOA, ALDOB, ALG1, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, ALMS1, ALOX5AP, ALPL, ALS2, ALX1, ALX3, ALX4, AMACR, AMMECR1, AMN, AMPD1, AMPD2, AMT, ANG, ANK3, ANKLE2, ANKO5, ANKRD11, ANKTRX1, ANO10, ANO3, AP1S1, AP1S2, AP3B1, AP4B1, AP4E1, AP4M1, AP4S1, AP5Z1, APOA1, APOE, APP, APTX, AR, ARFGEF2, ARG1, ARHGAP31, ARHGEF10, ARHGEF6, ARHGEF9, ARID1A, ARID1B, ARL13B, ARL6, ARNT1, ARSA, ARSB, ARSE, ARSI, ARV1, ARX, ASAH1, ASCL1, ASL, ASNS, ASPA, ASPM, ASS1, ASXL1, ASXL3, ATAD3A, ATCAY, ATIC, ATL1, ATL3, ATM, ATN1, ATP13A2, ATP1A2, ATP1A3, ATP2A1, ATP2A2, ATP2B3, ATP2B4, ATP5E, ATP6AP2, ATP6V0A2, ATP7A, ATP7B, ATP8A2, ATPAF2, ATR, ATRX, ATXN1, ATXN10, ATXN2, ATXN3, ATXN7, ATXN8OS, AUH, AUT22, AUTS2, B3GALNT2, B3GLCT, B4GALNT1, B4GAT1, B4GLAT1, B9D1, B9D2, BAG3, BBIP1, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, BCAP31, BCKDHA, BCKDHB, BCKDK, BCL11A, BCOR, BCORL1, BCS1L, BDNF, BEAN1, BEST1, BICD2, BIN1, BLOC1S3, BLOC1S6, BMP4, BOLA3, BRAF, BRAT1, BRWD3, BSCL2, BSND, BTD, BVES, C12ORF57, C12ORF65, C19ORF12, C9ORF72, CA8, CACNA1A, CACNA1B, CACNA1D, CACNA1G, CACNA1H, CACNA1S, CACNA2D2, CACNB4, CACNG2, CAMTA1, CAPN1, CAPN3, CARS2, CASC5, CASK, CASR, CAV3, CBL, CC2D1A, CC2D2A, CCDC22, CCDC28B, CCDC78, CCDC88A, CCDC88C, CCM2, CCND2, CCT5, CD207, CD320, CD36, CD59, CD96, CDH15, CDK11A, CDK5RAP2, CDKL5, CDKN1C, CDKON, CEADD, CENPE, CENPF, CENPJ, CEP104, CEP120, CEP135, CEP152, CEP290, CEP41, CEP63, CERS1, CFL2, CHAT, CHCHD10, CHCHD2, CHD2, CHD7, CHD8, CHKB, CHMP1A, CHMP2B, CHN1, CHRM3, CHRNA1, CHRNA2, CHRNA4, CHRNA7, CHRNB1, CHRNB2, CHRND, CHRNE, CHRNG, CHSY1, CISD2, CISH, CIT, CIZ1, CLCN1, CLCN2, CLCN4, CLCNKA, CLCNKB, CLIC2, CLN3, CLN5, CLN6, CLN8, CLP1, CLPP, CNBP, CNKSR2, CNOT3, CNTN1, CNTN6, CNTNAP2, CNTNAP4, COA5, COA8, COASY, COG1, COG4, COG5, COG6, COG7, COG8, COL12A1, COL18A1, COL4A1, COL4A2, COL4A3BP, COL6A1, COL6A2, COL6A3, COL7A1, COLQ, COQ2, COQ4, COQ5, COQ6, COQ7, COQ8A, COQ9, COX10, COX15, COX20, COX6A1, COX6B1, COX7B, CP, CP2, CPA6, CPLANE1, CPLX1, CPOX, CPT2, CR1, CRBN, CREBBP, CRYAB, CSF1R, CSF2RB, CSNK2A1, CSPP1, CST3, CSTB, CTBP1, CTC1, CTCF, CTDP1, CTFD, CTNNB1, CTNND2, CTSD, CTSF, CUL4B, CWF19L1, CYP11B2, CYP27A1, CYP2U1, CYP7B1, D2HGDH, DAG1, DARS1, DARS2, DBT, DCAF17, DCAF8, DCHS1, DCTN1, DCX, DDC, DDHD1, DDHD2, DDOST, DDX3X, DEAF1, DEPDC5, DES, DGUOK, DHCR24, DHCR7, DHFR, DHH, DHTKD1, DIAPH1, DIAPH3, DIS3L2, DISP1, DKC1, DLAT, DLD, DLG3, DLL1, DLL4, DMD, DNAH9, DNAJB2, DNAJB6, DNAJC19, DNAJC5, DNAJC6, DNM1, DNM1L, DNM2, DNMT1, DNMT3A, DOCK6, DOCK7, DOCK8, DOK7, DOLK, DPAGT1, DPM1, DPM2, DPM3, DPYD, DPYS, DRD2, DRD3, DSC3, DST, DTNBP1, DYNC1H1, DYNC2H1, DYRK1A, DYSF, EARS2, EBF3, EBP, ECHS1, ECM1, EDN3, EDNRB, EED, EEF1A2, EEF2, EFHC1, EFTUD2, EGR2, EHMT1, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S3, EIF4E, EIF4G1, ELK1, ELOVL4, ELOVL5, ELP1, EMD, EMX2, EN2, ENO3, ENTPD1, EOGT, EOMES, EP300, EPB41L1, EPM2A, ERBB4, ERCC1, ERCC2, ERCC5, ERCC6, ERCC8, ERLIN1, ERLIN2, ESCO2, ETFA, ETFB, ETFDH, ETHE1, EXOC8, EXOSC3, EXOSC8, EZH2, F2, F5, FA2H, FADD, FAM126A, FAM134B, FANCB, FAR1, FARS2, FASTKD2, FAT4, FBLN5, FBXL4, FBXO38, FBXO7, FCGR2B, FECH, FGA, FGD1, FGD4, FGF10, FGF12, FGF14, FGF8, FGFR1, FGFR2, FGFR3, FGFRL1, FH, FHL1, FIG4, FKBP14, FKRP, FKTN, FLAD1, FLNA, FLNC, FLRT1, FLVCR1, FLVCR2, FMR1, FOLR1, FOXC1, FOXG1, FOXH1, FOXP1, FOXP2, FOXP3, FOXRED1, FREM1, FRG1, FRMD7, FRMPD4, FRRS1L, FTCD, FTL, FTO, FTSJ1, FUS, FXN, FZD9, GAA, GABBR2, GABRA1, GABRB2, GABRB3, GABRD, GABRG2, GAD1, GALC, GALNS, GAMT, GAN, GARS, GAS1, GATAD2B, GATM, GBA, GBA2, GBE1, GCDH, GCH1, GCSH, GDAP1, GDI1, GDNF, GFAP, GFER, GFM1, GFPT1, GGSN, GIGYF2, GJA1, GJB1, GJB3, GJC2, GK, GLA, GLB1, GLDC, GLI2, GLI3, GLRA1, GLRB, GLUL, GLYCTK, GM2A, GMPPB, GNAL, GNAO1, GNB1, GNB4, GNE, GNPAT, GNS, GOSR2, GP1BA, GPC3, GPHN, GPR143, GPSM2, GRIA3, GRID2, GRIK2, GRIN1, GRIN2A, GRIN2B, GRIP1, GRM1, GRM7, GRN, GSS, GTPBP3, GUF1, GUSB, GYG1, GYS1, HACE1, HADHA, HADHB, HAL, HARS1, HARS2, HCCS, HCFC1, HCN1, HCN4, HDAC4, HDAC6, HDAC8, HECW2, HEPACAM, HERC1, HERC2, HESX1, HEXA, HEXB, HFE, HGSNAT, HIBCH, HINT1, HIVEP, HK1, HMBS, HMGB3, HMGCS2, HNRNP2B1, HNRNPA1, HNRNPDL, HNRNPH2, HNRNPU, HOXA1, HOXD10, HPCA, HPD, HPRT1, HPS1, HPS3, HPS4, HPS5, HPS6, HPSE2, HRAS, HSD17B10, HSD17B4, HSPB1, HSPB3, HSPB8, HSPD1, HTRA1, HTRA2, HTT, HUWE1, HYAL1, IBA57, ICAM1, ICK, IDS, IDUA, IER3IP1, IFIH1, IFRD1, IFT140, IFT172, IFT27, IGBP1, IGF1, IGHMBP2, IKBKAP, IKBKG, IL11RA, IL1RAPL1, IL1RN, INF2, INPP5E, INS, IQSEC2, IRX5, ISCA2, ISCU, ISPD, ITGA7, ITM2B, ITN2B, ITPA, ITPR1, JMJD1C, JRK, KANK1, KANSL1, KARS, KAT6A, KAT6B, KATNB1, KBTBD13, KCNA1, KCNA2, KCNB1, KCNC1, KCNC3, KCND3, KCNE1L, KCNH1, KCNJ1, KCNJ10, KCNJ11, KCNJ2, KCNK19, KCNK9, KCNMA1, KCNQ2, KCNQ3, KCNT1, KCTD17, KCTD7, KDM5C, KDM6A, KIAA0586, KIF11, KIF1A, KIF1B, KIF1BP, KIF1C, KIF21A, KIF2A, KIF4A, KIF5A, KIF5C, KIF7, KIFBP, KIRREL3, KLF8, KLHL15, KLHL40, KLHL41, KMT2A, KMT2B, KMT2D, KMT5B, KNL1, KPTN, KRAS, KRIT1, KRT5, L1CAM, L2HGDH, LAMA1, LAMA2, LAMB1, LAMB2, LAMC3, LAMP2, LARGE, LARGE1, LARS2, LAS1L, LBR, LDB3, LDHA, LETM1, LGI1, LHX4, LIAS, LIG4, LIMS2, LINS1, LIPT1, LITAF, LMBRD1, LMNA, LMNB1, LMNB2, LMOD3, LPIN1, LPIN2, LRP2, LRP4, LRPPRC, LRRK2, LRSAM1, LYRM7, LYZ, LZTFL1, MAG, MAGEL2, MAGI2, MAGT1, MAMLD1, MAN1B1, MAOA, MAP2K1, MAPK10, MAPT, MARS1, MARS2, MASP1, MAT1A, MATR3, MBD5, MBTPS2, MCEE, MCM3AP, MCOLN1, MCPH1, MCPH2, MECP2, MECR, MED12, MED13L, MED17, MED23, MED25, MEF2C, MEGF10, MET, MFN2, MFSD2A, MFSD8, MGAT2, MICU1, MID1, MID2, MKKS, MKS1, MLC1, MMAA, MMAB, MMACHC, MMADHC, MME, MOCS1, MOCS2, MOGS, MORC2, MPDU1, MPDZ, MPI, MPV17, MPZ, MRE11, MRPL44, MRPS22, MSX1, MSX2, MTFMT, MTHFR, MTM1, MTMR14, MTMR2, MTO1, MTOR, MTPAP, MTR, MTRR, MTTP, MUSK, MUT, MVK, MYCN, MYF6, MYH14, MYH2, MYH3, MYH7, MYH9, MYL2, MYO5A, MYOT, MYPN, MYT1L, NAA10, NACC1, NADK2, NAGA, NAGLU, NALCN, NAT8L, NBN, NDE1, NDP, NDRG1, NDST1, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA2, NDUFA4, NDUFA9, NDUFAF1, NDUFAF2, NDUFAF3, NDUFAF4, NDUFAF5, NDUFAF6, NDUFB3, NDUFB9, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, NEB, NECAP1, NEDD4L, NEFH, NEFL, NEMO, NEU1, NEXMIF, NF1, NFIA, NFIX, NFU1, NGF, NGLY1, NHEJ1, NHLRC1, NHS, NIPA1, NIPBL, NKX2-1, NLGN3, NLGN4X, NLRP12, NLRP3, NOD2, NODAL, NOG, NOL3, NONO, NOP56, NOS2, NOS3, NOTCH1, NOTCH2, NOTCH3, NPC1, NPC2, NPHP1, NPHP3, NPRL3, NR2F1, NRAS, NRG1, NRXN1, NSD1, NSD2, NSDHL, NSF5, NSUN2, NT5C2, NTRK1, NTRK2, NUBPL, NXF5, OCLN, OCRL, OFD1, OGT, OPA1, OPA3, OPHN1, OPTN, ORC1, OTC, OTX2, PABPN1, PACS1, PAFAH1B1, PAH, PAK3, PANK2, PARK2, PARK7, PAX6, PC, PCBD1, PCDH12, PCDH19, PCK2, PCNT, PDCD10, PDE6D, PDE8B, PDGFB, PDGFRB, PDHA1, PDK3, PDSS1, PDSS2, PDYN, PEX1, PEX10, PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3, PEX5, PEX6, PEX7, PFKM, PFN1, PGAM2, PGAP1, PGAP2, PGK1, PGM1, PHF6, PHF8, PHGDH, PHKA1, PHOX2A, PHOX2B, PHYH, PIEZO2, PIGA, PIGL, PIGN, PIGO, PIGT, PIGV, PIK3CA, PIK3R2, PIK3R5, PINK1, PLA2G6, PLCB1, PLEC, PLEKHG2, PLEKHG4, PLEKHG5, PLK4, PLP1, PMM2, PMP22, PNKD, PNKP, PNPL86, PNPLA2, PNPLA6, PNPO, POGLUT1, POGZ, POLA1, POLG, POLG2, POLR1C, POLR3A, POLR3B, POMGNT1, POMGNT2, POMK, POMT1, POMT2, PORCN, PPOX, PPP2R1A, PPP2R2B, PPP2R5D, PPT1, PQBP1, PRDM12, PREPL, PRF1, PRICKLE1, PRICKLE2, PRIMA1, PRKAG2, PRKCG, PRKCH, PRKDC, PRKN, PRKRA, PRNP, PRODH, PROP1, PRPH, PRPH2, PRPS1, PRRT2, PRRX1, PRSS12, PRX, PSAP, PSEN1, PSEN2, PTCH1, PTCHD1, PTEN, PTF1A, PTPN11, PTS, PURA, PUS1, PVRL1, PYCR2, PYGM, QARS1, QDPR, RAB18, RAB39B, RAB3GAP1, RAB3GAP2, RAB40AL, RAB7A, RABGGTA, RAD21, RAD50, RAF1, RAI1, RANBP2, RAPSN, RARS1, RARS2, RASA1, RBBP8, RBCK1, RBFOX1, RBFOX3, RBM10, RBM8A, RBPJ, REEP1, REEP2, RELN, RET, RETREG1, RFT1, RIN2, RIT1, RLIM, RMND1, RNASEH2A, RNASEH2B, RNASEH2C, RNASET2, RNF113A, RNF135, RNF170, RNF216, RNU4ATAC, ROBO3, ROGDI, ROR2, RPGRIP1L, RPIA, RPL10, RPS6KA3, RPSK6C1, RRM2B, RSK2, RTN2, RTN4IP1, RTTN, RUBCN, RXYLT1, RYR1, SACS, SALL4, SAMHD1, SATB2, SBF1, SBF2, SCARB2, SCN10A, SCN11A, SCN1A, SCN1B, SCN2A, SCN3A, SCN4A, SCN5A, SCN8A, SCN9A, SCO1, SCO2, SCP2, SDCCAG8, SDHA, SDHAF1, SDHB, SDHD, SELENON, SEPN1, SEPSECS, SEPT9, SERAC1, SERPINI1, SETBP1, SETD2, SETD5, SETX, SGCA, SGCB, SGCD, SGCE, SGCG, SGSH, SH3TC2, SHANK2, SHANK3, SHH, SHOC2, SHPK, SHROOM4, SIGMAR1, SIK1, SIL1, SIX3, SIX6, SKI, SLC12A5, SLC12A6, SLC13A5, SLC16A2, SLC17A5, SLC19A3, SLC1A2, SLC1A3, SLC1A4, SLC20A2, SLC22A5, SLC25A1, SLC25A12, SLC25A15, SLC25A19, SLC25A20, SLC25A22, SLC25A26, SLC25A3, SLC25A4, SLC25A46, SLC2A1, SLC30A10, SLC33A1, SLC35A1, SLC35A2, SLC35C1, SLC38A8, SLC39A8, SLC3A1, SLC46A1, SLC4A1, SLC4A4, SLC52A2, SLC52A3, SLC5A7, SLC6A1, SLC6A3, SLC6A5, SLC6A8, SLC9A6, SLC9A9, SMAD2, SMAD3, SMARCA2, SMARCA4, SMARCB1, SMC1A, SMC3, SMCHD1, SMN1, SMN2, SMPD1, SMS, SNAP25, SNAP29, SNCA, SNCAIP, SNCB, SNIP1, SNORD118, SNX14, SNX3, SOBP, SOD1, SORL1, SOS1, SOX10, SOX2, SOX3, SPAST, SPATA5, SPEG, SPG11, SPG20, SPG21, SPG7, SPR, SPTAN1, SPTBN2, SPTLC1, SPTLC2, SQSTM1, SRD5A3, SRPX2, SSR4, ST3GAL3, ST3GAL5, STAC3, STAG2, STAMBP, STAT1, STIL, STIM1, STRADA, STUB1, STX1B, STXBP1, SUCLA2, SUCLG1, SUMF1, SUN1, SUN2, SUOX, SURF1, SYN1, SYNE1, SYNE2, SYNGAP1, SYNJ1, SYP, SYT14, SYT2, SZT2, TACO1, TAF1, TAF15, TAF2, TANGO2, TARDBP, TARS2, TAS2R38, TAZ, TBC1D20, TBC1D24, TBC1D7, TBCD, TBCE, TBCK, TBK1, TBL1XR1, TBP, TBR1, TBX1, TCAP, TCF20, TCF4, TCTN1, TCTN2, TCTN3, TDGF1, TDP1, TECPR2, TECR, TFAP2A, TFAP2B, TFG, TG, TGFB1, TGFB2, TGFBR1, TGFBR2, TGIF1, TGM6, TH, THAP1, THOC2, TIA1, TICAM1, TIMM8A, TIRAP, TK2, TLR3, TLR5, TM4SF20, TMCO1, TMEM126A, TMEM126B, TMEM138, TMEM165, TMEM187, TMEM216, TMEM231, TMEM237, TMEM240, TMEM43, TMEM5, TMEM67, TMEM70, TMLHE, TNF, TNFSF4, TNNI2, TNNT1, TNPO3, TOR1A, TOR1AIP1, TP63, TPK1, TPM2, TPM3, TPP1, TRAF3, TRAPPC11, TRAPPC9, TREM2, TREX1, TRIM2, TRIM32, TRIO, TRIP12, TRIP4, TRMT10A, TRMT5, TRPM6, TRPM7, TRPS1, TRPV4, TSC1, TSC2, TSEN15, TSEN2, TSEN34, TSEN54, TSFN, TSHB, TSHR, TSPAN7, TTBK2, TTC19, TTC21B, TTC8, TTI2, TTN, TTP1, TTPA, TTR, TUBA1A, TUBA4A, TUBA8, TUBB, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBG1, TUBGCP4, TUBGCP6, TUFM, TUSC3, TWIST1, TWNK, TYMP, TYROBP, UBA1, UBA5, UBE2A, UBE3A, UBQLN2, UCHL1, UMPS, UNC80, UNC93B1, UPB1, UPF3B, UQCRB, UQCRQ, UROD, UROS, USP27X, USP9X, VAMP1, VANGL1, VAPB, VARS2, VAX1, VCP, VDAC1, VEGFA, VHL, VIPAS39, VLDLR, VMA21, VPS11, VPS13A, VPS13B, VPS35, VPS37A, VPS53, VRK1, WAC, WASHC5, WDPCP, WDR26, WDR45, WDR48, WDR62, WDR73, WDR81, WFS1, WNK1, WNT10A, WNT3, WNT5A, WNT7A, WT1, WWOX, XBP1, XK, XPR1, XRCC4, YAP1, YARS1, YWHAE, YY1, ZBTB16, ZBTB18, ZC4H2, ZCCHC12, ZDHHC15, ZDHHC9, ZEB2, ZFR, ZFYVE26, ZFYVE27, ZIC2, ZIC3, ZMYM3, ZNF335, ZNF41, ZNF423, ZNF674, ZNF711, ZNF81

Disorders that can be tested for include:

Amytrophic lateral sclerosis
Ataxias
Charcot-Marie-Tooth
Congenital myasthenic syndrome
Dystonias
Epilepsies
Hereditary neuropathy with liability to pressure palsies (HNPP)
Huntington Disease
Mitochondrial myopathies
Muscular dystrophies
Myotonia and paramyotonia congenita
Spastic paraplegias
Spinal bulbar muscular atrophy
Parkinsons
Tyrosine hydroxylase deficiency

81161x1, 81171x1, 81173x1, 81175x1, 81177x1, 81178x1, 81179x1, 81180x1, 81181x1, 81182x1, 81183x1, 81184x1, 81185x1, 81187x1, 81188x1, 81189x1, 81204x1, 81234x1, 81236x1,81243x1, 81284x1, 81302x1, 81321x1, 81324x1, 81336x1, 81343x1, 81403x9, 81404x48, 81405x90, 81406x91, 81407x23, 81408x12, 81460x1, 81479x5 (81271x1, 81479x1)

The CPT codes provided are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

Blood - 5ml
Saliva - contact us for a kit
gDNA - 5μg

Turn around time is ~8 weeks from sample receipt.

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