Frequently Asked Questions about the Genomic Inform™  Test

Genetic testing can identify variants in your DNA that put you at an increased risk for developing diseases later in life such as cancer, heart conditions, clotting conditions, inflammatory bowel diseases, inherited kidney disorders, age-related macular degeneration and more. It can also determine your carrier status for rare inherited disorders before you pass a harmful variant on to your child.
Once you've ordered your test online, our clinical coordinators will get in touch to walk you through the testing process. They'll send you a saliva collection kit and a test requisition form. If you have any questions, you'll be able to speak with a genetic counselor. Then you'll fill out the test requisition form with your physician, sending it and your saliva sample to us using the prepaid postage. Our affiliated sequencing partners will sequence your DNA and securely transmit the data to Variantyx where it will be analyzed and interpreted by our board-certified medical geneticists. In ~8 weeks, your full clinical report will be ready.

Once your completed test requisition form and saliva sample are received, it takes ~8 weeks to deliver the final clinical report.

Whole genome sequencing is not covered for preventative care. Direct patient payment is required for this test.

The Genomic Inform™ test costs $2,819. It is more expensive than many of the direct-to-consumer tests advertised on TV and in social media because it uses whole genome sequencing technology. This advanced sequencing technology looks at >98% of your DNA, while other sequencing technologies look at between <0.01% and 1.5% of your DNA. Having more DNA sequenced results in a more expensive test. However, it also provides significantly more value - enabling detection of more potentially harmful variants in more genes for a significantly more complete analysis.

Frequently Asked Questions about Genetic Testing

DNA is a sequence of A's, T's, C's and G's organized into coding regions that make up the approximately 20,000 genes which provide instructions for making proteins. These proteins are responsible for growth and development as well as traits such as eye color. Non-coding regions help control how and when genes are used.

Your genome is your complete DNA sequence, including both coding and non-coding regions.

More than 99% of your DNA is identical to everyone else’s. A variant is a change in the DNA code. A variant can be a normal genetic difference that does not cause medical problems, or it can be a harmful variant that causes an abnormality or disease. The purpose of genetic testing is to identify changes in the DNA sequence that are the cause of an affected individual’s condition or that may predispose an individual to develop a condition later in life.

Our DNA is organized into 23 pairs of chromosomes. We have two copies of each gene - one inherited from our mother and one inherited from our father. We will pass one of those copies on to our children. If one copy contains the variant and one does not, we have a 50% chance of passing the variant on to an individual child. If both copies contain the variant, we have a 100% chance of passing the variant on to an individual child.

For most inherited disorders, two copies of a harmful variant are necessary for an individual to exhibit the symptoms. The one “good” copy without the variant is oftentimes sufficient to compensate for the harmful copy with the variant. If your DNA contains one copy of a harmful variant you are considered a carrier - you carry the variant, and may pass the variant on to your children, but you do not exhibit symptoms of the disorder. If your partner is also a carrier for the variant, your individual child has a 25% chance of inheriting the disorder and a 50% chance of being a carrier. For X-linked variants, the chance of your child being a carrier or inheriting the disorder is higher, particularly in boys who have one X chromosome and one Y chromosome.
Whole genome sequencing (WGS) uses the most advanced DNA sequencing technology available. It looks at more than 98% of your DNA. Other types of sequencing look at only a small amount of your DNA, ranging from 0.01% to 1.5%. By looking at more of your DNA it's possible to look at many different types of variants across all of your genes. 

Clinical whole genome sequencing webinar

Listen in as we look into the significant advantages of clinical whole genome testing over current NGS testing methods, including exome testing, for diagnosis of rare inherited disorders.

Watch Now

The Genomic InformTM test takes an in-depth look at thousands of your genes to identify and understand the harmful changes in your DNA, if any.

You're probably interested to see what a report that analyzes so many of your genes looks like.

Fill out the form to the right and we'll send you an anonymized sample report that describes findings for:

checkmark risk of age-related macular degeneration

checkmark possible risk of familial hypercholesterolemia, which can cause elevated cholesterol levels

checkmark carrier risk of Pierson syndrome (a recessive disorder that predominately affects the kidneys and eyes) and several SEPN-1 related disorders (predominately recessive muscle-related disorders)

 

Download A Sample Genomic InformTM Test Report


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