NGS Research Scientist

The NGS Research Scientist is an on-site full-time position at Variantyx, Inc. located in Framingham, MA. The Scientist participates in the development of high-complexity molecular assays using next-generation sequencing methods in order to identify somatic and germline variants contributing to tumor development using manual and automated methods.  Assays developed will cover a broad range of applications including but not limited to characterization of primary tumors and metastases, monitoring cancer recurrence, and detection of minimum residual disease. 



  • In collaboration with senior research personnel, develop and execute high-complexity workflows using next generation sequencing technologies that will detect and monitor somatic and germline variants that drive tumor formation, resistance and spread.
  • Participate in design and execution of feasibility experiments to evaluate competing methods in, but not limited to, nucleic acid isolation, DNA and RNA library preparation, hybrid capture and next-generation sequencing
  • Develop and assess quality metrics to gauge sample integrity and suitability for analysis at each stage of testing. 
  • Participate in design and execution of validation studies as required by CLIA, CAP and NYSDOH guidelines.
  • Development of standard operating procedures (SOPs) and equipment maintenance and testing protocols to ensure compliance while maintaining all required records and documentation for continual inspection readiness. 
  • Participate in troubleshooting assay and equipment issues.
  • Collaborates with IT and Bioinformatic scientists to ensure clinical samples are properly tracked (through LIMS) and analytically processed (analysis pipelines).  
  • Participate in test launch and post launch activities. 
  • Participate in verification and validation studies for process improvements, new equipment, and new technology transfer.
  • Assist with laboratory inventory to ensure productivity goals are met.
  • Maintain positive working relationships and effective communication within and across teams.
  • Other related duties as required.



  • MSc or PhD in Biology, Genomics, Molecular Oncology or related life science
  • 3-5 years relevant work experience including next generation sequencing technologies and familiarity with automated liquid handlers.
  • Experience in development and validation of high-complexity molecular assays in a regulated environment is strongly preferred. 

To apply for this job email your details to

Framingham, MA